55 years old Patient has long standing DM II, HTN, IHD, had retinopathy peripheral neuropathy, He's on aspirin, atorvastatin, Gliclazide, metformin, metoprolol, irbesartan. His lab investigations reveal: EGFR :27, Cr: 3mg/dl, Urea 75mg/dl .. renal failure What medication should be stopped?