A 35-year-old man has 1-month history of chronic cough that produces blood-tinged sputum. He has no significant medical history. On examination, he appears thin and ill. Temp 38.5 C, BP 125/75mmHg, HR 95/min, and RR 30/min, Chest auscultation shows crepitation over the upper lung fields. The remainder of the physical examination is unremarkable. Chest x-ray shows bilateral upper lobe cavitary lesions. Acid Fast Bacilli (AFB) are found on direct sputum smear. Which of the following is the most appropriate therapy for this patient?
سؤال مجاني 3 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: D. Isoniazid, rifampin, pyrazinamide, and ethambutol
Smear-positive active pulmonary TB is treated with RIPE: rifampin, isoniazid, pyrazinamide and ethambutol for 2 months, then isoniazid + rifampin for 4 months (with pyridoxine). Mono- or dual therapy (B, C) is never used for active TB because of resistance; isoniazid alone is a latent-TB regimen. Option A is not first-line.
ليش كل خيار صح أو غلط
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A
ليش غلط
The standard regimen is the four first-line drugs, including isoniazid and rifampin; ciprofloxacin is not part of the traditional regimen.
✓ Step Up To Medicine 6th Edition 2024 (TB and its treatment).pdf · p. 6 -
B
ليش غلط
TB must never be treated with one antibiotic, because resistance to INH develops rapidly when it is used alone.
✓ Step Up To Medicine 6th Edition 2024 (TB and its treatment).pdf · p. 6 -
C
ليش غلط
INH plus rifampin is only the 4-month continuation phase; the first 2 months need all four drugs (rifampin, isoniazid, pyrazinamide, ethambutol).
✓ TB and Its TTx.pdf · p. 4 -
D
ليش صح
Active TB is treated with the four-drug regimen (INH, rifampin, pyrazinamide, ethambutol) for 2 months, then rifampin and INH for 4 months.
✓ Step Up To Medicine 6th Edition 2024 (TB and its treatment).pdf · p. 6
- المصدر
- TB and Its TTx.pdf · p. 4
Step Up To Medicine 6th Edition 2024 (TB and its treatment).pdf · p. 6 - المحاضرة
- Tuberculosis · Pulmonology · Module B
- ظهر في
- Respi bank