A 48-yaer-old man has ischemic heart disease and on oral nitrates therapy. Certain drugs especially phosphodiesterase inhibitors can cause hazardous reactions such as severe hypotension when used by patient on nitrate therapy. What is the single best agent to produce such harmful interaction?
سؤال مجاني 2 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: D. Sildenafil
Sildenafil (a PDE-5 inhibitor) with nitrates causes severe/marked hypotension, so nitrates are contraindicated in patients using PDE inhibitors. Atenolol, hydralazine and verapamil are not phosphodiesterase inhibitors.
ليش كل خيار صح أو غلط
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A
ليش غلط
Atenolol is a cardio-selective β1-blocker, not a phosphodiesterase inhibitor, so it is not the drug behind the nitrate interaction.
✓ (Y4)-(M B) Therapeutic HTN Slides.pdf · p. 33 -
C
ليش غلط
Verapamil is a CCB whose dangerous combination is with beta-blockers (severe cardiac depression), not with nitrates.
✓ Cardiology 🫀.pdf · p. 10 -
D
ليش صح
Sildenafil is a phosphodiesterase inhibitor; with a nitrate it causes severe hypotension, so nitrates are contraindicated.
✓ Cardiology 🫀.pdf · p. 10
- المصدر
- CARDIOLOGY- ISCHEMIC HEART DISEASES (IHDs).pdf · p. 5
Cardiology 🫀.pdf · p. 10 - المحاضرة
- Ischemic Heart Disease · Cardiology · Module B
- ظهر في
- Cardio bank