A 35-year-old woman has acute slurred speech and confusion, T 38.5, BP 180/100. Hb 8.5, platelets 30,000, LDH 800, creatinine 2.5. What confirms the diagnosis?
سؤال مجاني 1 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: A. ADAMTS-13 deficiency
✓ مطابق للمصدر
Hematology🩸.pdf · p. 31
Neurological symptoms, fever, thrombocytopenia, haemolysis (anaemia, LDH 800) and renal impairment are the TTP pentad. TTP is caused by autoantibodies against, or deficiency of, ADAMTS13, and low ADAMTS13 activity (<10%) confirms it.
- Complement dysregulation underlies atypical HUS, which lacks prominent fever/neurological features.
- The Coombs test is negative in TTP (non-immune).
- A raised reticulocyte count is non-specific.
- المصدر
- Hematology🩸.pdf · p. 31
Hematology🩸.pdf · p. 30 - المحاضرة
- MAHA · Hematology · Module C
- ظهر في
- MED41 ♂ EOM C