A 70 year old woman has been in long-standing poor health, with severe diabetes mellitus and rheumatoid arthritis. Her physician notes that she appears pale and orders a hematocrit, which shows a result of 35%. Examination of the blood smear reveals a microcytic anemia. The physician is considering a differential diagnosis of iron deficiency anemia versus anemia of chronic disease. Which of the following laboratory determinations would be most helpful in distinguishing these conditions?
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الإجابة: D. Serum ferritin
Serum ferritin reflects iron stores: it is low in iron deficiency but normal/high in anaemia of chronic disease (iron trapped in stores; ferritin is also an acute-phase reactant). Serum iron is the tempting option, but it is low in both conditions, so it cannot separate them. Target cells (thalassaemia) and basophilic stippling (lead/sideroblastic) and the marrow E:G ratio do not distinguish IDA from ACD.
- المصدر
- HEME-01 Microcytic Anemia [Notes].pdf · p. 8
Anemia.pdf · p. 3 - المحاضرة
- Anaemia · Hematology · Module C
- ظهر في
- Hema bank