A 24-year-old male student with severe acute hepatitis B infection is evaluated because of mental status changes. He has had nausea, vomiting, and fatigue for 5 to 7 days and jaundice for 3 days. Prothrombin time: 28 s (18-22), total serum bilirubin: 12.6 mg/dL (0.3-1.2), AST: 1640 U/L (10-30), serum ammonia: 126 (15-45). After 24 h he developed grade II hepatic encephalopathy. Which of the following is the most appropriate immediate management?
سؤال مجاني 1 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
المصادر مختلفة. ملفات الدفعة فيها إجابتين، وما نرجّح وحدة على الثانية. سبب كل وحدة في الشرح تحت:
- إجابة: E. Intravenous glucose, proton pump inhibitor
- إجابة ثانية: C. lactulose, intravenous glucose
This is acute liver failure (acute HBV, INR/PT prolonged, encephalopathy) in a previously normal liver. The course lecture warns that treatments used for chronic liver disease may be inappropriate in ALF and that lactulose is potentially dangerous (gas/bloating that interferes with transplant); management is supportive: correct hypoglycaemia (IV glucose/dextrose) and PPI to prevent GI bleeding, with early transplant referral. However, OnlineMedEd and Step-Up notes in the same channel list lactulose for ALF encephalopathy, which is why the old bank keyed C (lactulose + IV glucose). A low-protein diet is not recommended.
- المصدر
- Y4 - MD (Hepatology) Acute Liver Failure.pdf · p. 20
Acute liver injury & failure.pdf · p. 11
Acute liver injury & failure.pdf · p. 10 - المحاضرة
- Acute Liver Injury & Failure · Gastroenterology & Liver · Module C
- ظهر في
- GI bank