A 23-year-old man presents to the emergency department with severe pain and swelling in both hands. He reports similar episodes in the past affecting different joints. He has no history of trauma or recent infections. On examination, he is in distress due to pain, has mild pallor, and his hands appear swollen and tender without signs of infection. Laboratory findings are as follows: Hemoglobin: 7.9 g/Dl, WBC: 11,200/mm³, Platelet count: 340,000/mm³, Reticulocyte count: 10%. Peripheral blood smear shows Sickle-shaped red blood cells. What is the most likely diagnosis?
سؤال مجاني 1 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
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الإجابة: B. Sickle cell disease (HbSS)
Recurrent painful episodes, painful swollen hands (dactylitis / hand-foot syndrome, a vaso-occlusive event), anaemia with high reticulocytes, and sickle cells on the smear point to sickle cell disease (HbSS).
- Rheumatoid arthritis would not explain haemolytic anaemia with sickled RBCs.
- ITP and haemophilia A cause bleeding, not painful crises with sickled cells; the platelet count here is normal.
- المصدر
- Hematology🩸.pdf · p. 19
Hematology🩸.pdf · p. 20 - المحاضرة
- Haemoglobinopathies (SCD, Thalassaemia) · Hematology · Module C
- ظهر في
- MED42 ♂ EOM C