A 28-year-old man presents to the emergency department with dark urine, jaundice, and fatigue that started two days ago. He reports a recent febrile illness, for which he took aspirin and an unknown antibiotic. He denies any history of liver disease, chronic anemia, or recent trauma. Vital signs: HR 98 bpm, BP 122/80 mmHg, RR 16, Temp 37°C. On examination: Mild scleral icterus and pallor, No hepatosplenomegaly, No signs of active bleeding. Laboratory findings: Hemoglobin: 8.5 g/Dl, Reticulocyte count: 7%, LDH: Elevated, Haptoglobin: Low. Peripheral blood smear: Bite cells, Heinz bodies and Blister cell. Direct Coombs test was negative. What is the most likely diagnosis?
سؤال مجاني 4 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: A. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
This is acute haemolysis (low haptoglobin, high LDH, reticulocytosis, dark urine) after an oxidative trigger (infection, aspirin, an antibiotic). The smear shows bite cells and Heinz bodies and the DAT is negative. That combination is G6PD deficiency.
- AIHA would be DAT-positive with spherocytes.
- Hereditary spherocytosis shows spherocytes, not bite cells or Heinz bodies.
- المصدر
- HEME-02 Normocytic Anemia [Notes].pdf · p. 20
Hematology🩸.pdf · p. 16 - المحاضرة
- Haemolytic Anaemia · Hematology · Module C
- ظهر في
- MED42 ♂ EOM C