A 35-year-old women came with joint pain and swelling hands. She has elevated anti double strand antibody and negative complements. Renal biopsy shows wire loop lesion and mesangial proliferation. what of the following is the most likely diagnosis?
سؤال مجاني 1 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: B. lupus nephritis
A young woman with arthritis, raised anti-dsDNA, low complement (C3) and wire-loop lesions on biopsy has lupus nephritis. Wire loops come from subendothelial immune-complex deposits, typical of class IV.
- IgA nephropathy has normal C3 and mesangial IgA deposits.
- FSGS and membranous nephropathy are nephrotic lesions without anti-dsDNA or wire loops.
ليش كل خيار صح أو غلط
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A
ليش غلط
IgA nephropathy has normal C3 and appears days after a URTI or gastroenteritis, with no anti-dsDNA or wire-loop lesion.
✓ Glomerular Diseases [Notes].pdf · p. 14 -
B
ليش صح
Wire looping of the glomerulus on light microscopy is the biopsy finding of lupus nephritis type IV (versus tram-tracking in MPGN).
✓ Glomerular Diseases [Slides].pdf · p. 42 -
C
ليش غلط
FSGS shows sclerosis on light microscopy with podocyte effacement on EM, not wire loops.
✓ Glomerular Diseases [Notes].pdf · p. 13 -
D
ليش غلط
Membranous nephropathy shows a thick GBM and spike-and-dome subepithelial immune deposits, not wire loops.
✓ Glomerular Diseases [Notes].pdf · p. 13
- المصدر
- Glomerular Diseases [Slides].pdf · p. 42
Glomerular Diseases [Notes].pdf · p. 14 - المحاضرة
- Glomerular Diseases · Nephrology · Module C
- ظهر في
- MED42 ♂ EOM C · MED41 ♂ EOM C · MED41 ♀ EOM C