A 45-year-old man with a known history of granulomatosis with polyangiitis (GPA) presents to the emergency department with shortness of breath, hemoptysis, and oliguria. Laboratory results reveal a duplication in his serum creatinine. What is the most likely the underlying pathology?
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الإجابة والشرح
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الإجابة: C. RPGN
GPA is an ANCA vasculitis (lung + kidney). It typically causes rapidly progressive glomerulonephritis (RPGN) with crescents. That explains haemoptysis plus oliguria and a rapid rise in creatinine.
- Membranous nephropathy is nephrotic, and Alport syndrome is hereditary; neither causes this acute pulmonary-renal picture.
ليش كل خيار صح أو غلط
-
A
ليش غلط
FSGS is a nephrotic disease (sclerosis of the glomeruli with nonselective proteinuria), not an ANCA vasculitis with lung and kidney involvement.
✓ Glomerular Diseases [Notes].pdf · p. 1 -
B
ليش غلط
Membranous nephropathy is a nephrotic disease (subepithelial immune deposits, nonselective proteinuria); GPA with haemoptysis and oliguria is an ANCA nephritic process.
✓ Glomerular Diseases [Notes].pdf · p. 1 -
C
ليش صح
GPA is ANCA-mediated (c-ANCA) with lung and kidney involvement, and the glomerulonephritis is often rapidly progressive (RPGN), giving an abrupt creatinine rise.
✓ Glomerular Diseases [Notes].pdf · p. 3 -
D
ليش غلط
Alport syndrome is a hereditary type IV collagen defect with deafness, anterior lenticonus and glomerulonephritis, not an ANCA vasculitis.
✓ Glomerular Diseases [Notes].pdf · p. 5
- المصدر
- Glomerular Diseases [Notes].pdf · p. 3
Glomerular Diseases [Notes].pdf · p. 10 - المحاضرة
- Glomerular Diseases · Nephrology · Module C
- ظهر في
- MED42 Compre C