A 40-year-old man presents with fluctuating ptosis, diplopia, and proximal muscle weakness that worsens with activity and improves with rest. Which mechanism best explains his symptoms?
سؤال مجاني 2 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: C. Autoantibodies against postsynaptic acetylcholine receptors
Fluctuating ptosis, diplopia and proximal weakness that worsens with activity and improves with rest is myasthenia gravis, caused by autoantibodies against postsynaptic acetylcholine receptors at the neuromuscular junction.
- Antibodies against presynaptic calcium channels (B) = Lambert-Eaton syndrome, where strength improves with repeated use.
- Demyelination of peripheral nerves (D) = GBS.
ليش كل خيار صح أو غلط
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A
ليش غلط
Weakness that worsens with muscle use and improves with rest is the pattern of myasthenia gravis, an antibody disease of the neuromuscular junction, rather than axonal degeneration of motor neurons.
✓ Guillain Barre Syndrome + mysthenia gravis.pdf · p. 3 -
B
ليش غلط
Presynaptic calcium-channel antibodies cause Lambert-Eaton syndrome, where weakness improves with exercise; this patient gets worse with activity.
✓ Neurology 🧠.pdf · p. 42 -
C
ليش صح
Myasthenia gravis is caused by autoantibodies against postsynaptic acetylcholine receptors, causing ptosis, diplopia and proximal weakness that worsen with use and improve with rest.
✓ Guillain Barre Syndrome + mysthenia gravis.pdf · p. 3 -
D
ليش غلط
Demyelination of peripheral nerves is Guillain-Barre syndrome: ascending flaccid paralysis with reduced or absent reflexes, not fluctuating, activity-dependent weakness.
✓ Guillain Barre Syndrome + mysthenia gravis.pdf · p. 4
- المصدر
- Guillain Barre Syndrome + mysthenia gravis.pdf · p. 3
Neurology 🧠.pdf · p. 42 - المحاضرة
- GBS & Myasthenia Gravis · Neurology · Module C
- ظهر في
- MED43 ♂ Quiz C · MED43 ♀ Compre