26-year-old female was found unconscious in her apartment after an apparent suicide attempt. Empty paracetamol tablets were found beside her, along with green-colored vomitus. She was brought to the emergency department. Despite repeated attempts to wake her, she remained drowsy and difficult to arouse. On examination: difficult to arouse, jaundiced. Cardiovascular and respiratory examination: normal Laboratory investigations: ALT = 1300 U/L, AST = 800 U/L , Total bilirubin = 11 mg/dL, INR = 5 Which of the following medications is most likely to improve her survival?
سؤال مجاني 1 من 10 اليوم · اشترك وكمّل بدون حد
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الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: C. N-acetylcysteine
This is paracetamol (acetaminophen)-induced acute liver failure: jaundice, encephalopathy, very high transaminases and INR 5. IV N-acetylcysteine refills liver glutathione and has been shown to reduce mortality in paracetamol-related ALF, even late in the course.
- FFP and vitamin K (B, D) only correct the INR. They do not improve survival, and the INR is needed to track prognosis.
- Activated charcoal alone (A) is only useful very early after ingestion.
- المصدر
- 6• Acute Liver Failure [Notes].pdf · p. 4
Acute liver failure.pdf · p. 3 - المحاضرة
- Acute Liver Injury & Failure · Gastroenterology & Liver · Module C
- ظهر في
- MED43 ♀ Compre