A 40-year-old African American woman has progressive shortness of breath. Her chest x-ray shows bilateral Hilar lymphadenopathy suggestive of sarcoidosis. She is also found to have elevated calcium levels. Which of the fallowing will also be likely to be elevated in this patient?
سؤال مجاني 7 من 10 اليوم · اشترك وكمّل بدون حد
اعرض الإجابة
الإجابة والشرح
ادخل لحسابك عشان نحفظ إجاباتك ونوريك أخطاءك.
الإجابة: D. 1, 25-dihydroxnyvitamin D
In sarcoidosis, granuloma macrophages express 1-alpha-hydroxylase, so 1,25-dihydroxyvitamin D (calcitriol) rises and causes hypercalcaemia. PTH is suppressed, PTHrP points to malignancy, and 25-OH vitamin D is not the form that rises.
ليش كل خيار صح أو غلط
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A
ليش غلط
PTHrP is ordered when malignancy is suspected; sarcoidosis raises calcium through vitamin D, not PTHrP.
✓ Endocrine ✳️.pdf · p. 16 -
B
ليش غلط
In granulomatous disease like sarcoidosis the vitamin D level to check is the 1,25-dihydroxy form, not 25-hydroxyvitamin D.
✓ Endocrine ✳️.pdf · p. 16 -
C
ليش غلط
With granulomatous disease the hypercalcemia is PTH-independent: PTH is low (and PTHrP is not the cause), with high vitamin D metabolites leading to the granulomatous work-up.
✓ Calcium and Parathyroid.pdf · p. 49 -
D
ليش صح
In sarcoidosis, macrophages show increased 1-alpha-hydroxylase activity, raising 1,25-dihydroxyvitamin D synthesis and causing hypercalcemia.
✓ Calcium and Parathyroid.pdf · p. 6
- المصدر
- Calcium and Parathyroid.pdf · p. 6
Endocrine ✳️.pdf · p. 16 - المحاضرة
- Parathyroid & Calcium Disorders · Endocrinology · Module B
- ظهر في
- Endo bank